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Energy homeostasis & metabolic regulation investigated for downstream effects on energy balance, substrate partitioning, and metabolic adaptation in preclinical research models

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In contrast, empagliflozin, a sodium-glucose cotransporter 2 inhibitor (SGLT-2i), has been shown to slow DR progression compared with dipeptidyl peptidase-4 inhibitor (DPP-4i) therapy over an average follow-up of eight months [6]

By activating GLP-1 receptors, Saxenda and Trulicity help reduce appetite, increase feelings of fullness, and improve blood sugar control

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When considering the function of gut-derived GLP-1, it is difficult to ignore the metabolic effects of nutrient-derived energy in addition to the direct actions of GLP-1 itself